| Id | Title | Sales | Debut | Genre | Developer | Publisher |
|---|---|---|---|---|---|---|
| 1 | Super Smash Bros. Melee | 7.41 million[1][28] | November 21, 2001 | HAL Laboratory | Nintendo | |
| 2 | Mario Kart: Double Dash | 6.88 million[1][29] | November 14, 2003 | Nintendo EAD | Nintendo | |
| 3 | Super Mario Sunshine | 5.91 million[1][3] | July 19, 2002 | Nintendo EAD | Nintendo | |
| 4 | The Legend of Zelda: The Wind Waker | 4.43 million[1][2] | December 13, 2002 | Nintendo EAD | Nintendo | |
| 5 | Luigi's Mansion | 3.33 million[1][2][b] | September 14, 2001 | Nintendo EAD | Nintendo | |
| 6 | Metroid Prime | 2.84 million[2] | November 18, 2002 | Retro Studios | Nintendo | |
| 7 | Animal Crossing | 2.7 million[c][2] | December 14, 2001 | Nintendo EAD | Nintendo | |
| 8 | Mario Party 4 | 2.46 million[2] | October 21, 2002 | Hudson Soft | Nintendo | |
| 9 | Pokémon Colosseum | 2.41 million[2] | November 21, 2003 | Genius Sonority | NintendoThe Pokémon Company | |
| 10 | Mario Party 5 | 2.17 million[2] | November 10, 2003 | Hudson Soft | Nintendo | |
| 11 | Mario Party 7 | 2.08 million[2] | November 7, 2005 | Hudson Soft | Nintendo | |
| 12 | Paper Mario: The Thousand-Year Door | 1.91 million[2] | July 22, 2004 | Intelligent Systems | Nintendo | |
| 13 | Star Fox Adventures | 1.82 million[2] | September 23, 2002 | Rare | Nintendo | |
| 14 | Sonic Adventure 2: Battle | 1.73 million[d] | December 20, 2001 | Sonic Team USA | Sega | |
| 15 | Mario Party 6 | 1.63 million[2] | November 18, 2004 | Hudson Soft | Nintendo | |
| 16 | Pikmin | 1.60 million[2] | October 26, 2001 | Nintendo EAD | Nintendo | |
| 17 | Resident Evil 4 | 1.60 million[34] | January 11, 2005 | Capcom Production Studio 4 | Capcom | |
| 18 | Sonic Adventure DX: Director's Cut | 1.60 million[35] | June 18, 2003 | Sonic Team | Sega | |
| 19 | Super Mario Strikers | 1.60 million[2] | November 18, 2005 | Next Level Games | Nintendo | |
| 20 | The Legend of Zelda: Twilight Princess | 1.43 million[2] | December 2, 2006 | Nintendo EAD | Nintendo | |
| 21 | Pokémon XD: Gale of Darkness | 1.42 million[2] | August 4, 2005 | Genius Sonority | NintendoThe Pokémon Company | |
| 22 | Sonic Heroes | 1.42 million[35] | December 30, 2003 | Sonic Team | Sega | |
| 23 | Sonic Mega Collection | 1.37 million[e] | November 10, 2002 | Sonic Team | Sega | |
| 24 | Resident Evil | 1.35 million[34] | March 22, 2002 | Capcom Production Studio 4 | Capcom | |
| 25 | Kirby Air Ride | 1.35 million[2] | July 11, 2003 | HAL Laboratory | Nintendo | |
| 26 | Final Fantasy Crystal Chronicles | 1.30 million[36] | August 8, 2003 | The Game Designers Studio | Nintendo | |
| 27 | Resident Evil Zero | 1.25 million[34] | November 12, 2002 | Capcom | Capcom | |
| 28 | Mario Golf: Toadstool Tour | 1.22 million[2][f] | July 28, 2003 | Camelot Software Planning | Nintendo | |
| 29 | Donkey Konga | 1.18 million[2] | December 12, 2003 | Namco | Nintendo | |
| 30 | Mario Power Tennis | 1.16 million[2] | October 28, 2004 | Camelot Software Planning | Nintendo | |
| 31 | Star Wars Rogue Squadron II: Rogue Leader | 1.13 million[h] | November 18, 2001 | Factor 5 | LucasArts | |
| 32 | Pikmin 2 | 1.12 million[2] | April 29, 2004 | Nintendo EAD | Nintendo | |
| 33 | Metroid Prime 2: Echoes | 1.10 million[2] | November 15, 2004 | Retro Studios | Nintendo | |
| 34 | Soulcalibur II | 1.09 million[i] | March 27, 2003 | Namco | Namco | |
| 35 | Mario Superstar Baseball | 1.05 million[2] | July 21, 2005 | Namco | Nintendo | |
| 36 | Sonic Gems Collection | 1 million[21][22] | August 11, 2005 | Sonic Team | Sega |
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